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NASH is one of the leading causes of chronic liver disease worldwide and may lead to serious consequences.

Are You at Risk?
REGENERATE NASH fibrosis study patient and participant REGENERATE NASH fibrosis study patient and participant

What does it mean to have NASH?

NASH occurs when fat builds up in the liver, creating inflammation and causing
scarring known as fibrosis. It is found in people who drink little or no alcohol.

How serious is NASH?

Over time, as more and more scar tissue replaces healthy tissue, the liver is unable to function normally. The medical term for this is cirrhosis. At that point, the current treatment option is transplantation. NASH is now the second leading cause for liver transplant in the U.S.1 and is expected to be the leading cause by 2020.2 NASH can also lead to liver cancer.

Risk factor: liver cirrhosis and fibrosis Risk factor: liver cirrhosis and fibrosis

Who is at risk for NASH?

Certain factors can put you at higher risk for NASH:

Risk factor: Pre-diabetes type 2 diabetes Risk factor: Pre-diabetes type 2 diabetes
Diabetes

NASH is more common in patients with pre-diabetes or type 2 diabetes.

Risk factor: Obesity overweight Risk factor: Obesity overweight
Weight

NASH is closely associated with being overweight or obese.

Risk factor: High blood pressure Risk factor: High blood pressure
High Blood Pressure

People with high blood pressure are at increased risk for NASH.

Risk factor: High blood pressure Risk factor: High blood pressure
High cholesterol

High cholesterol is a condition associated with NASH.

Risk factor: Person hispanic enthicity Risk factor: Person hispanic enthicity
Ethnic background

NASH is more commonly seen in Hispanics than other ethnic groups.

Risk factor: Age 40-60 Risk factor: Age 40-60
Age

NASH is most often found in people between the ages of 40 and 60.

Are you at risk?

How is NASH treated?

Lifestyle: Weight reduction Lifestyle: Weight reduction
Lifestyle: Exercise Lifestyle: Exercise
Lifestyle: Healthy diet Lifestyle: Healthy diet
Lifestyle: No alcohol Lifestyle: No alcohol

Currently, there are no medications approved for the treatment of NASH. Doctors recommend reducing weight, eating a healthy diet, increasing physical activity, and avoiding alcohol. While this does not cure the disease, it may slow its progression.
The only treatment for liver cirrhosis due to NASH is a liver transplant.

What can you do?

Clinical researchers are conducting the REGENERATE study, testing the safety and effectiveness of an investigational medication for patients with NASH and liver scarring called fibrosis.

Learn more about risk factors and options you may consider.

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Use ClinTrialConnect to learn more about NASH and the REGENERATE study, communicate with study sites, and download and share resources with loved ones.

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