NASH occurs when fat builds up in the liver, creating inflammation and causing
scarring known as fibrosis. It is found in people who drink little or no alcohol.
Over time, as more and more scar tissue replaces healthy tissue, the liver is unable to function normally. The medical term for this is cirrhosis. At that point, the current treatment option is transplantation. NASH is now the second leading cause for liver transplant in the U.S.1 and is expected to be the leading cause by 2020.2 NASH can also lead to liver cancer.
Certain factors can put you at higher risk for NASH:
NASH is more common in patients with pre-diabetes or type 2 diabetes.
NASH is closely associated with being overweight or obese.
People with high blood pressure are at increased risk for NASH.
High cholesterol is a condition associated with NASH.
NASH is more commonly seen in Hispanics than other ethnic groups.
NASH is most often found in people between the ages of 40 and 60.
Currently, there are no medications approved for the treatment of NASH. Doctors recommend reducing weight, eating a healthy diet, increasing physical activity, and avoiding alcohol. While this does not cure the disease, it may slow its progression.
The only treatment for liver cirrhosis due to NASH is a liver transplant.
Clinical researchers are conducting the REGENERATE study, testing the safety and effectiveness of an investigational medication for patients with NASH and liver scarring called fibrosis.
Learn more about risk factors and options you may consider.
Use ClinTrialConnect to learn more about NASH and the REGENERATE study, communicate with study sites, and download and share resources with loved ones.