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About Nash The REGENERATE Study About Clinical Trials Share

NASH is a serious liver disease that’s become increasingly common. It can lead to liver failure, cancer, the need for a liver transplant, and death.

Are you at risk?
REGENERATE NASH fibrosis study patient and participant REGENERATE NASH fibrosis study patient and participant

What is NASH?

Nonalcoholic Steatohepatitis (NASH) is a chronic condition in which the buildup of fat and inflammation in the liver may eventually lead to severe scarring called fibrosis, which may advance and require a liver transplant. It is currently the second leading cause of liver transplant in the U.S.1 Because people with NASH rarely experience symptoms, the disease can progress for years without a diagnosis.

Currently, there are no medications approved for the treatment of NASH. But researchers are working toward changing that by conducting clinical trials.

Answer the following questions to find out more about NASH and relevant risk factors you may have. Your answers will not be stored or shared.

NASH is commonly found in people between the ages of 40 and 60.

1. How old are you?

Risk factor: Age 40-60 Risk factor: Age 40-60
NASH is commonly seen in Hispanics.

2. What is your ethnic origin or race? Select all that apply.

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Risk factor: Person hispanic enthicity Risk factor: Person hispanic enthicity
NASH is associated with pre-diabetes, type 2 diabetes, being overweight or obese, high cholesterol and high blood pressure.
Risk factor: Pre-diabetes type 2 diabetes Risk factor: Pre-diabetes type 2 diabetes
Pre-Diabetes or
Type 2 Diabetes
Risk factor: Obesity overweight Risk factor: Obesity overweight
Obesity
Risk factor: High cholesterol high blood pressure Risk factor: High cholesterol high blood pressure
High Cholesterol and High Blood Pressure

3. Have you had any of the following conditions? Select all that apply.

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Alcoholic Liver Disease Liver Transplant or Placement on Liver Transplant List Hepatocellular Carcinoma (HCC) Primary Biliary Cirrhosis or Primary Biliary Cholangitis
Primary Sclerosing Cholangitis Autoimmune Hepatitis Overlap Syndrome Wilson’s Disease, Hemochromatosis, or Iron Overload Alpha-1 Antitrypsin (A1AT) Deficiency
NASH is usually first suspected when routine blood work shows abnormal liver test results or an imaging test shows a buildup of fat in the liver. However, not all people with NASH have abnormal liver tests.

4. Has your doctor discussed any of the following with you? Select all that apply.

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Risk factor: blood work, liver test Risk factor: blood work, liver test
When there is no obvious reason (such as medications, hepatitis, biopsies, or excessive use of alcohol) for an abnormal liver blood test result, doctors may perform imaging studies. If fat is seen in the liver, then a biopsy is necessary
to diagnose NASH.

5. Has your doctor conducted any of the following tests to confirm fatty liver disease and/or NASH? Select all that apply.

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Risk factor: liver testing, blood work, liver biopsy Risk factor: liver testing, blood work, liver biopsy
Inflammation may develop when fat builds up in the liver. Continued inflammation in patients with NASH, in response to the fat buildup, may lead to liver scarring known as fibrosis. Over time, as more and more scar tissue replaces healthy tissue, the liver cannot function normally. This condition is called cirrhosis.
Risk factor: liver cirrhosis and fibrosis Risk factor: liver cirrhosis and fibrosis

6. Have you been told you have cirrhosis (Fibrosis Stage 4) of the liver?

 
 
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A clinical trial called REGENERATE is studying an investigational medication for patients with NASH and liver scarring (fibrosis).

Your answers indicate that REGENERATE may be an option for you. To find out if you may be eligible to participate, talk to your doctor or contact a study site.

Have questions about clinical trials? Learn more about what they are and what to expect.

To find a REGENERATE study site near you, please enter your location.

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A clinical trial called REGENERATE is studying an investigational medication for patients with NASH and liver scarring (fibrosis).

Based on your answers, we’re not sure if REGENERATE is an option for you. But by answering these questions, you’ve taken an important step toward assessing your potential risk for NASH. You should continue the conversation with your doctor.

Lifestyle: Weight reduction Lifestyle: Weight reduction
Lifestyle: Exercise Lifestyle: Exercise
Lifestyle: Healthy diet Lifestyle: Healthy diet
Lifestyle: No alcohol Lifestyle: No alcohol

If you’re diagnosed with NASH, your doctor will likely recommend lifestyle changes, such as weight loss, following a balanced and healthy diet, and increasing physical activity. This can help slow down the progression of NASH. You and your doctor can decide what approach is best for you.

Get more information about lifestyle modification here.

Learn more about NASH
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To connect with the study site, you must first register with ClinTrialConnect.

Use ClinTrialConnect to learn more about NASH and the REGENERATE study, communicate with study sites, and download and share resources with loved ones.

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